Antisynthetase Syndrome and Autoantibodies: A Literature Review and Report of 4 Cases
Identifieur interne : 000A71 ( Main/Exploration ); précédent : 000A70; suivant : 000A72Antisynthetase Syndrome and Autoantibodies: A Literature Review and Report of 4 Cases
Auteurs : Flávia Luiza Marin [Brésil] ; Henrique Pereira Sampaio [Brésil]Source :
- The American Journal of Case Reports [ 1941-5923 ] ; 2019.
Abstract
With the advent and advancement of autoantibodies, there has been progress in the diagnosis, prognosis, and treatment of rheumatologic diseases. Antisynthetase syndrome (ASS) is a great example of a disease that initially was described as arthritis, myositis, interstitial lung disease, mechanic’s hands, Raynaud’s phenomenon, and fever in the presence of the anti-JO-1 antibody, but nowadays it presents with a different spectrum related to new antibodies.
We describe 4 patients with antisynthetase syndrome who were diagnosed with antibodies specific for myositis associated with different clinical findings. All patients responded to immunosuppressive therapy, and rituximab was the most used.
It is necessary to search for specific autoantibodies related to the syndrome in suspected clinical cases and in other rheumatological diseases refractory to the usual treatment.
Url:
DOI: 10.12659/AJCR.916178
PubMed: 31344020
PubMed Central: 6676984
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antisynthetase Syndrome and Autoantibodies: A Literature Review and Report of 4 Cases</title><author><name sortKey="Marin, Flavia Luiza" sort="Marin, Flavia Luiza" uniqKey="Marin F" first="Flávia Luiza" last="Marin">Flávia Luiza Marin</name><affiliation wicri:level="3"><nlm:aff id="af1-amjcaserep-20-1094">Postgraduate Program in Pathophysiology in Medical Clinic, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Postgraduate Program in Pathophysiology in Medical Clinic, São Paulo State University (UNESP), Botucatu, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Sampaio, Henrique Pereira" sort="Sampaio, Henrique Pereira" uniqKey="Sampaio H" first="Henrique Pereira" last="Sampaio">Henrique Pereira Sampaio</name><affiliation wicri:level="3"><nlm:aff id="af2-amjcaserep-20-1094">Department of Rheumatology, Division of Medical Clinic, Section of Medicine, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Rheumatology, Division of Medical Clinic, Section of Medicine, São Paulo State University (UNESP), Botucatu, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31344020</idno><idno type="pmc">6676984</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676984</idno><idno type="RBID">PMC:6676984</idno><idno type="doi">10.12659/AJCR.916178</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000402</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000402</idno><idno type="wicri:Area/Pmc/Curation">000402</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000402</idno><idno type="wicri:Area/Pmc/Checkpoint">000A01</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A01</idno><idno type="wicri:Area/Ncbi/Merge">000847</idno><idno type="wicri:Area/Ncbi/Curation">000847</idno><idno type="wicri:Area/Ncbi/Checkpoint">000847</idno><idno type="wicri:Area/Main/Merge">000A71</idno><idno type="wicri:Area/Main/Curation">000A71</idno><idno type="wicri:Area/Main/Exploration">000A71</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Antisynthetase Syndrome and Autoantibodies: A Literature Review and Report of 4 Cases</title><author><name sortKey="Marin, Flavia Luiza" sort="Marin, Flavia Luiza" uniqKey="Marin F" first="Flávia Luiza" last="Marin">Flávia Luiza Marin</name><affiliation wicri:level="3"><nlm:aff id="af1-amjcaserep-20-1094">Postgraduate Program in Pathophysiology in Medical Clinic, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Postgraduate Program in Pathophysiology in Medical Clinic, São Paulo State University (UNESP), Botucatu, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Sampaio, Henrique Pereira" sort="Sampaio, Henrique Pereira" uniqKey="Sampaio H" first="Henrique Pereira" last="Sampaio">Henrique Pereira Sampaio</name><affiliation wicri:level="3"><nlm:aff id="af2-amjcaserep-20-1094">Department of Rheumatology, Division of Medical Clinic, Section of Medicine, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Rheumatology, Division of Medical Clinic, Section of Medicine, São Paulo State University (UNESP), Botucatu, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author></analytic><series><title level="j">The American Journal of Case Reports</title><idno type="eISSN">1941-5923</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Case series</bold></p><p><bold>Patient: Female, 25 • Female, 39 • Male, 27 • Female, 42</bold></p><p><bold>Final Diagnosis: Antisynthetase syndrome</bold></p><p><bold>Symptoms: Arthralgia • dyspnea • muscle weakness</bold></p><p><bold>Medication: —</bold></p><p><bold>Clinical Procedure: Immunosuppressive therapy</bold></p><p><bold>Specialty: Rheumatology</bold></p><sec><title>Objective:</title><p><bold>Rare disease</bold></p></sec><sec><title>Background:</title><p>With the advent and advancement of autoantibodies, there has been progress in the diagnosis, prognosis, and treatment of rheumatologic diseases. Antisynthetase syndrome (ASS) is a great example of a disease that initially was described as arthritis, myositis, interstitial lung disease, mechanic’s hands, Raynaud’s phenomenon, and fever in the presence of the anti-JO-1 antibody, but nowadays it presents with a different spectrum related to new antibodies.</p></sec><sec><title>Case Report:</title><p>We describe 4 patients with antisynthetase syndrome who were diagnosed with antibodies specific for myositis associated with different clinical findings. All patients responded to immunosuppressive therapy, and rituximab was the most used.</p></sec><sec><title>Conclusions:</title><p>It is necessary to search for specific autoantibodies related to the syndrome in suspected clinical cases and in other rheumatological diseases refractory to the usual treatment.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Cavagna, L" uniqKey="Cavagna L">L Cavagna</name></author><author><name sortKey="Nu O, L" uniqKey="Nu O L">L Nuño</name></author><author><name sortKey="Scire, Ca" uniqKey="Scire C">CA Scirè</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mirrakhimov, Ae" uniqKey="Mirrakhimov A">AE Mirrakhimov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rojas Serrano, J" uniqKey="Rojas Serrano J">J Rojas-Serrano</name></author><author><name sortKey="Herrera Bringas, D" uniqKey="Herrera Bringas D">D 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